AOD-9604

What is AOD-9604?

AOD-9604 is a synthetic 16-amino-acid peptide modeled on the C-terminal region of human growth hormone, the stretch usually labeled hGH 176–191. The sequence begins with a tyrosine and contains two cysteine residues joined by a single intramolecular disulfide bond, which closes part of the chain into a small loop. V8 Peptides supplies it as a lyophilized powder in sealed 5 mg glass vials.

In the laboratory, AOD-9604 serves as a reference fragment for investigators who want to examine the C-terminal portion of growth hormone separately from the full 191-residue protein. Published preclinical work has concentrated on adipocyte and lipid-metabolism models, and on how the fragment's signaling profile compares with intact hGH in the same systems.

Where it is used in the lab

• Adipocyte and lipid-metabolism assays in cell and tissue models
• Comparative studies of hGH fragments against the full-length hormone
• Analytical method development for disulfide-containing peptides

For laboratory research use only; not for human consumption.

AOD-9604 specifications

Reconstitution & storage for research

AOD-9604 arrives as a dry lyophilized cake, so the working concentration is set entirely by the volume of diluent you add. Adding 1 mL of diluent to the 5 mg vial gives 5 mg/mL; adding 2 mL gives 2.5 mg/mL, and 2.5 mL gives 2 mg/mL. At 2.5 mg/mL, a 100 µL aliquot contains 250 µg of peptide. Our reconstitution calculator runs the same arithmetic for any vial size and diluent volume.

A sterile diluent such as bacteriostatic water is the usual choice for multi-use research vials. Direct the diluent slowly down the inside wall of the vial instead of onto the powder, then swirl gently until the solution is clear. Do not shake; vigorous agitation can foam or shear the material. Because the molecule depends on an intact disulfide bond, keep reducing agents out of the diluent unless your protocol calls for them.

Storage conditions

• Unopened vial: refrigerate at 2–8 °C; move to −20 °C if the vial will sit for an extended period.
• Environment: keep the powder away from heat, moisture and direct light, and let a cold vial reach room temperature before opening so condensation does not form inside.
• After reconstitution: return the solution to 2–8 °C, label it with concentration and preparation date, and split it into aliquots if it will be sampled more than a few times.

Quality & testing

Every lot of AOD-9604 is analyzed by high-performance liquid chromatography (HPLC) before release, against a specification of ≥98% purity. The result is recorded on a batch-specific Certificate of Analysis, published on our COA page, so you can match the lot number on the vial to the document before the material enters your workflow.

• Measured HPLC purity, reported as a percentage
• Identity confirmation for the compound
• Batch / lot number and analytical test date
• Supplied form and storage conditions

Vials are sealed, labeled for research use and shipped within the United States in discreet packaging. Payment is by invoice or Zelle.

Related lab guides

• AOD-9604 research overview
• AOD-9604 reconstitution and storage
• How AOD-9604 purity is tested
• AOD-9604 chemical structure and synthesis
• Reconstitution calculator guide
• How to read a Certificate of Analysis

Labs running metabolic-signaling panels often keep these on the same shelf: Tesamorelin, MOTS-c, Cagrilintide.