Semaglutide is a GLP-1 analog (molecular formula C187H291N45O59) modified in several positions to extend its activity in research settings.
Structural features
Two design elements are central: amino-acid substitutions that resist DPP-4 degradation, and a fatty-acid (C18 diacid) side chain attached via a linker. The lipid chain promotes reversible binding to serum albumin in models, slowing clearance — the same half-life-extension strategy used in tirzepatide.
How it is made
Production uses solid-phase peptide synthesis followed by side-chain conjugation and purification, with HPLC and mass-spec verification confirming purity and identity.
Product page: Semaglutide research vials.
Research Use Only. Supplied strictly for laboratory research and development — not for human or veterinary use, consumption, or any therapeutic or diagnostic purpose. This article is research education, not usage guidance.