CJC-1295 without DAC — often referred to as modified GRF(1-29) — is a growth-hormone-releasing-hormone analog engineered with amino-acid substitutions that improve stability relative to native GHRH, but without the drug-affinity-complex (DAC) modification that dramatically extends half-life. It functions as a compact, short-acting tool compound for growth-hormone-axis research.
What the molecule is
The analog is built on the biologically active GHRH(1-29) scaffold, the truncated fragment that carries the receptor-activating information of the full 44-residue hormone. A small set of engineered substitutions blunts enzymatic cleavage, giving a peptide that is easy to assemble yet meaningfully more durable than the unmodified fragment. Its chemistry is detailed in the structure and synthesis article.
The "no DAC" distinction
The absence of the DAC group means this variant has a much shorter duration of action than CJC-1295 with DAC, which makes it a useful tool for studying pulsatile versus sustained receptor engagement. The two variants are commonly discussed as a matched pair for exactly this reason.
Mechanistic class
As a GHRH analog it works through the GHRH receptor, mirroring the pathway of sermorelin but with engineered stability. In practice it is frequently paired in research with selective secretagogues like ipamorelin to model combined upstream inputs.
Research context
The chemistry behind its stabilizing substitutions relates to general amino acid sequence principles, and reproducible results depend on documented identity and purity confirmed by HPLC purity analysis.
Position within the analog family
The no-DAC form occupies an intermediate research niche: its substitutions provide more proteolytic stability than an unmodified GHRH fragment, while the lack of an albumin-binding group keeps its signal shorter than the DAC-bearing design. That placement makes it a useful reference when an experiment needs to separate sequence stabilization from carrier-mediated persistence. Comparisons should account for receptor system, sampling schedule, and the different structural basis of each analog's duration.
Product page: CJC-1295 (No DAC) research vials.
Research Use Only. Supplied strictly for laboratory research and development — not for human or veterinary use, consumption, or any therapeutic or diagnostic purpose. This article is research education, not usage guidance.