Semax
ACTH(4-7) nootropic analog
$95.00
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Synthetic ACTH(4-10) heptapeptide analog studied for neurotrophic and cognitive-signaling mechanisms (BDNF/NGF). ≥98% HPLC purity.
Research applications
- 01BDNF/NGF expression research
- 02Neuronal-signaling models
- 03Cognitive-signaling studies
- Sizes
- 15 mg
- Purity
- ≥98%
- Molecular formula
- C37H51N9O10S
- Sequence / identity
- Met-Glu-His-Phe-Pro-Gly-Pro
- Supplied form
- Lyophilized powder
- Storage
- Refrigerate at 2–8 °C; −20 °C for long-term. Protect from heat, moisture & light.
- Container
- Sealed clear glass research vial
- ✓Compound identity & sequence
- ✓Measured purity (HPLC %)
- ✓Sequence / identity confirmation
- ✓Batch / lot number
- ✓Analytical test date
- ✓Supplied form & storage
Research Use Only. All products are sold strictly for laboratory research and development purposes only. Not for human or animal consumption. Not a drug, food, or cosmetic. By purchasing, you affirm you are a qualified researcher or institution.
Batch documentation
Batch-specific analytical documentation supports receiving, verification, and internal recordkeeping.
Storage guidance
Refrigerate the supplied material, freeze for long-term storage, and protect it from heat, moisture, and light.
Research-only labeling
Every vial is clearly identified for laboratory research use only — not for human or veterinary use.
What is Semax?
Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. The first four residues match positions 4–7 of adrenocorticotropic hormone (ACTH); the C-terminal Pro-Gly-Pro extension was added to slow enzymatic degradation. Like Selank, it was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences.
In research, Semax is used to study how a short ACTH-derived fragment influences neuronal signaling without the full hormone. Published work has focused on expression of neurotrophic factors such as BDNF and NGF in rodent brain tissue and cell models, along with transcriptomic studies in experimental ischemia models. V8 Peptides supplies it as lyophilized powder in a 15 mg vial.
Where it is used in the lab
- BDNF and NGF expression studies in neural tissue and cell models
- Transcriptomic profiling in preclinical neuroscience models
- Structure–activity work on ACTH-fragment analogs
For laboratory research use only; not for human consumption.
Semax specifications
| Compound | Semax |
|---|---|
| Class | Synthetic heptapeptide, ACTH(4–7) analog |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Vial size | 15 mg |
| Molecular formula | C37H51N9O10S |
| Purity | ≥98% (HPLC) |
| Supplied form | Lyophilized powder, sealed glass vial |
| Storage | 2–8 °C; −20 °C long-term; protect from heat, moisture and light |
| Documentation | Batch-specific COA |
Reconstitution & storage for research
Adding 3 mL of diluent to the 15 mg vial gives 5 mg/mL; adding 3.75 mL gives 4 mg/mL. At 4 mg/mL, a 25 µL aliquot contains 100 µg; at 5 mg/mL, a 20 µL aliquot contains the same 100 µg. For other volumes, the reconstitution calculator returns mg/mL and per-aliquot content instantly.
A sterile diluent such as bacteriostatic water is the usual choice for multi-use research vials. Let the diluent trickle down the vial wall, give the powder time to wet, and roll the vial between your fingers until no particles remain. Avoid shaking or vortexing at high speed. The N-terminal methionine can oxidize over time in solution, so keep stocks cold and tightly sealed.
Storage conditions
- Dry material: refrigerated (2–8 °C) on arrival; frozen (−20 °C) when it will not be used soon.
- Handling: limit exposure to warmth, moisture and light, and wipe the stopper with an alcohol swab before each puncture.
- Reconstituted material: store at 2–8 °C, note the date and mg/mL value in your lab record, and freeze single-use aliquots rather than refreezing one vial.
Quality & testing
Purity for Semax is measured by HPLC on a per-batch basis, with a ≥98% release threshold. The matching Certificate of Analysis is posted at /coa, which lets a lab verify what it received instead of relying on a generic specification sheet.
- Chromatographic purity (HPLC %)
- Identity check for the stated compound
- Lot number and test date for traceability
- Form supplied and recommended storage
Each sealed vial carries research-use labeling and ships domestically in the US. Orders are paid by invoice, Zelle or crypto.
Related lab guides
- Semax research overview
- Semax reconstitution and storage
- How Semax purity is tested
- Semax chemical structure and synthesis
- Selank vs. Semax: research comparison
- Reconstitution calculator guide
Its sister compound, built on the same Pro-Gly-Pro design: Selank.
Frequently Asked Questions
What purity is Semax?+
Semax is verified to ≥98% purity by HPLC, with identity confirmed by batch-specific analytical documentation (COA) published on our site.
How is Semax supplied and stored?+
Semax is supplied as a lyophilized powder. Refrigerate at 2–8 °C, or freeze at −20 °C for long-term storage. Protect from heat, moisture, and light.
Do you provide a Certificate of Analysis?+
Certificates of Analysis from our independent lab are published for tested lots (see the COA page), and we add more as reports come back. Contact us for the status of a specific product or lot.
Is Semax approved for human use?+
No. This product is sold strictly for laboratory research and development purposes and is not for human or animal consumption.
