PT-141 (Bremelanotide)

What is PT-141 (bremelanotide)?

PT-141, known by the generic name bremelanotide, is a synthetic cyclic heptapeptide with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH. It is structurally derived from Melanotan II and shares the same lactam-bridged ring; the difference is at the C-terminus, where PT-141 ends in a free carboxylic acid instead of an amide.

The compound is an agonist at melanocortin receptors, with most research attention on the MC3R and MC4R subtypes expressed in the central nervous system. Laboratories use it as a reference ligand for central melanocortin signaling and in neuroendocrine models. V8 Peptides supplies it as lyophilized powder in a 10 mg vial.

Where it is used in the lab

• MC4R and MC3R binding and functional assays
• Central melanocortin signaling studies
• Neuroendocrine research models

For laboratory research use only; not for human consumption.

PT-141 (Bremelanotide) specifications

Reconstitution & storage for research

Adding 2 mL of diluent to the 10 mg vial gives 5 mg/mL; adding 2.5 mL gives 4 mg/mL. Pick whichever makes your downstream arithmetic cleaner: at 4 mg/mL, a 50 µL aliquot contains 200 µg, while at 5 mg/mL the same 50 µL contains 250 µg. Our reconstitution calculator runs the same arithmetic for any vial size and diluent volume.

A sterile diluent such as bacteriostatic water is the usual choice for multi-use research vials. Direct the diluent slowly down the inside wall of the vial instead of onto the powder, then swirl gently until the solution is clear. Do not shake; vigorous agitation can foam or shear the material.

Storage conditions

• Unopened vial: refrigerate at 2–8 °C; move to −20 °C if the vial will sit for an extended period.
• Environment: keep the powder away from heat, moisture and direct light, and let a cold vial reach room temperature before opening so condensation does not form inside.
• After reconstitution: return the solution to 2–8 °C, label it with concentration and preparation date, and split it into aliquots if it will be sampled more than a few times.

Quality & testing

Every lot of PT-141 (Bremelanotide) is analyzed by high-performance liquid chromatography (HPLC) before release, against a specification of ≥98% purity. The result is recorded on a batch-specific Certificate of Analysis, published on our COA page, so you can match the lot number on the vial to the document before the material enters your workflow.

• Measured HPLC purity, reported as a percentage
• Identity confirmation for the compound
• Batch / lot number and analytical test date
• Supplied form and storage conditions

Vials are sealed, labeled for research use and shipped within the United States in discreet packaging. Payment is by invoice or Zelle.

Related lab guides

• PT-141 research overview
• PT-141 reconstitution and storage
• How PT-141 purity is tested
• PT-141 chemical structure and synthesis
• Where to buy PT-141 for research
• Reconstitution calculator guide

Related melanocortin-family research compounds: MT-2 (Melanotan II), KPV.